Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed at the endosomal membrane of B-cells, macrophages and dendritic cells. Poly I:… WebFigure 2.Treatment with poly(I:C) aggravated the histopathological lesions of salivary gland. (A) Infiltrated lymphocyte foci in the acinar tissue of salivary gland in different groups (HE, …
Activation of innate-adaptive immune machinery by poly(I:C ... - Gut
WebJan 19, 2024 · A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to human health. However, the long-term health consequences are largely … WebHistopathological evaluation reveals that the duodenum is the most affected by mucosal injury at 6 or 24 hours after injection of poly I:C. Study Data & Endpoints in Poly I:C … grand chase raven set elesis
poly(I:C) and LPS induce distinct IRF3 and NF‐κB signaling during …
WebJul 20, 2024 · Similarly, extended treatment with low-dose poly(I:C) or chronic infection of lymphocytic choriomeningitis virus clone 13 (LCMV C13)5 caused a functional decline of … WebThe assessed target genes (mx, vig1 and gig2) are canonical genes related to the antiviral response that codify for interferon induced proteins 34 and their upregulation in ZFL cells in response to poly(I:C), mounting a typical and strong antiviral response, has been previously characterised. 23,35,36 As shown in Fig. 3, ZFL cells respond to poly(I:C) by upregulating … WebThe Journal of Biological Chemistry grandchase ragnar