Tīmeklis2024. gada 4. maijs · Mechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in … TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we show that Qki directly interacts with single-stranded DNA.

Qki regulates myelinogenesis through Srebp2-dependent …

Tīmeklis2024. gada 23. maijs · We found the genome-wide co-binding of QKI-5 and SREBP2. Notably, the genomic distribution analysis revealed that the co-binding events between QKI-5 and SREBP2 highly occurred at the regions of the promoter/transcription start site (TSS), where active transcription was taken place in a lens cell-specific manner, … TīmeklisQki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu. starfish border

6721 - Gene ResultSREBF2 sterol regulatory element binding ...

Tīmeklis2024. gada 21. maijs · Reinforcing the critical role of QKI-5 for recruiting and activating SREBP2 on the promoters of cholesterol biosynthesis genes, the transcriptional … TīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, Qki depletion led to substantially reduced concentration of cholesterol in mouse brain, impairing proper myelin assembly. Our study demonstrated that Qki-Srebp2 … TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis … peterborough home and garden show 2016